CagriSema

Cagrilintide + Semaglutide

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55

authors mention this stack

21

ran the components concurrently

CagriSema (Cagrilintide + Semaglutide) appears in 55 author journeys (21 as actual concurrent use). Common goals: weight loss; Weight loss and appetite suppression; Weight loss. Typical doses reported: Cagrilintide 1mg, Semaglutide 2.4mg. Reported side effects include: Increased resting heart rate, constipation, headache

Typical doses reported

Cagrilintide 1mg
Semaglutide 2.4mg

Community-reported doses are not medical guidance.

How people are running it

24

Recommended / discussed

15

Currently running

11

Planning to run

7

Ran in the past

1

Unclear

What people use it for

weight lossWeight loss and appetite suppressionWeight losslong term weight maintenanceTo clear out the freezer stash of unused peptides, experiment during maintenance, and act as a backup protocol if Tirzepatide loses its effectiveness.Hunger suppression / weight loss

Sample reported outcomes

  • ✓ Weight loss down to 139 lbs
  • ✓ Successfully maintaining weight at 138-145 lbs (total loss of 110 lbs)
  • ✓ Broke stalls, reached goal weight, lost 105 lbs total, eliminated food noise
  • ✓ Discussed the chemical instability of combining Cagrilintide and Semaglutide into a single formulation
  • ✓ down 40lbs so far
  • ✓ Decided not to go through with it after research and community feedback
  • ✓ Unsuccessful; did not break the stall and caused severe gastrointestinal distress
  • ✓ Highly effective suppression of hunger and food noise for 4 days post-Wednesday dose, increased rate of weight loss, and significant relief from chronic joint and body pain/inflammation

Self-reported community experiences, not verified results.

Sample reported side effects

  • ⚠ Increased resting heart rate, constipation, headache
  • ⚠ Constipation (managed with Miralax), Cagrilintide warms the author up while Tirzepatide/Semaglutide keep them cold, dry mouth, no fatigue, high energy
  • ⚠ Constipation, warmth and energy (from Cagrilintide/Tesofensine), coldness (from Tirzepatide/Semaglutide)
  • ⚠ None
  • ⚠ Severe constipation ('pooping bricks') that almost resulted in an ER visit and required several enemas to resolve
  • ⚠ Very slight, transient nausea the day after Semaglutide and Cagrilintide administration
  • ⚠ Slight diarrhea and flatulence on the first day, which the author suspected was due to the Cagrilintide component.
  • ⚠ Not stated