Cagrilintide + Retatrutide + Tirzepatide

Cagrilintide + Retatrutide + Tirzepatide

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28

authors mention this stack

16

ran the components concurrently

Cagrilintide + Retatrutide + Tirzepatide (Cagrilintide + Retatrutide + Tirzepatide) appears in 28 author journeys (16 as actual concurrent use). Common goals: Weight loss and appetite suppression; Transitioning from Tirzepatide to Retatrutide due to depression and severe anhedonia at high doses (10-11mg) of Tirzepatide. Cagrilintide is stacked to provide appetite suppression and eliminate food noise during the transition, as Retatrutide alone was insufficient for appetite control. Metformin is used concurrently to manage insulin resistance.; Weight loss ('go as low as possible and eventually fade out'). Typical doses reported: Cagrilintide 0.25mg, Retatrutide 1mg, Tirzepatide 15mg. Reported side effects include: Anhedonia resolved by lowering the Tirzepatide dose. Experienced a temporary increase in resting heart rate upon starting Retatrutide.

Typical doses reported

Cagrilintide 0.25mg
Retatrutide 1mg
Tirzepatide 15mg

Community-reported doses are not medical guidance.

How people are running it

10

Currently running

8

Planning to run

7

Ran in the past

4

Recommended / discussed

What people use it for

Weight loss and appetite suppressionTransitioning from Tirzepatide to Retatrutide due to depression and severe anhedonia at high doses (10-11mg) of Tirzepatide. Cagrilintide is stacked to provide appetite suppression and eliminate food noise during the transition, as Retatrutide alone was insufficient for appetite control. Metformin is used concurrently to manage insulin resistance.Weight loss ('go as low as possible and eventually fade out')To break a weight loss stallconsidering stack adjustment options to manage tolerance/appetite returnDiscussed as a triple stack for weight loss

Sample reported outcomes

  • ✓ Broke the weight loss stall and weight is moving again. Cagrilintide provided excellent appetite suppression ('best appetite suppression i ever had').
  • ✓ Very effective appetite suppression (did not want to eat anything, full with two bites)
  • ✓ lost 3-4 lbs a week (best combo tried so far at 2mg Reta), but adding 4mg Retatrutide caused extreme hunger munchies and fatigue
  • ✓ The last 15 lbs easily fell off and the author successfully reached their weight goal.
  • ✓ Resulted in zero appetite and improved blood pressure (99/62 AM to 109/72 PM compared to over 140 previously) and lower resting heart rate (70-72).
  • ✓ Successfully broke her weight loss stall and allowed her to slide into her final goal weight (127 lbs)
  • ✓ seems to work
  • ✓ 70 pounds lost in total.

Self-reported community experiences, not verified results.

Sample reported side effects

  • ⚠ Anhedonia resolved by lowering the Tirzepatide dose. Experienced a temporary increase in resting heart rate upon starting Retatrutide.
  • ⚠ Fatigue, too much injecting / turning into a pin cushion
  • ⚠ fatigue, extreme hunger munchies (when Retatrutide was increased to 4mg)
  • ⚠ Severe fatigue from Cagrilintide (noted as a 'soul sucker' at doses above 0.5mg).
  • ⚠ Stomach is much more acidic; nausea during the first two weeks of adding Cagrilintide.
  • ⚠ Felt nauseous for a couple of days when Cagrilintide was first added
  • ⚠ Feeling freezing cold all the time, potential muscle loss.
  • ⚠ Craved sweets and hot all the time (noted from prior Retatrutide use)