Retatrutide + Tesamorelin

Retatrutide + Tesamorelin

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60

authors mention this stack

33

ran the components concurrently

Retatrutide + Tesamorelin (Retatrutide + Tesamorelin) appears in 60 author journeys (33 as actual concurrent use). Common goals: not stated; Weight loss and body composition; Weight loss and visceral fat reduction. Typical doses reported: Retatrutide 3mg, Tesamorelin 1mg. Reported side effects include: No major side effects mentioned, but noted a gelling issue with Tesamorelin when a syringe was dropped.

Typical doses reported

Retatrutide 3mg
Tesamorelin 1mg

Community-reported doses are not medical guidance.

How people are running it

24

Currently running

17

Planning to run

11

Recommended / discussed

9

Ran in the past

1

Unclear

What people use it for

not statedWeight loss and body compositionWeight loss and visceral fat reductionBoosting testosterone, muscle preservation, and maintaining a significant calorie deficit for weight loss.weight loss, visceral adipose tissue (VAT) reductioncutting, maintaining and gaining strength

Sample reported outcomes

  • ✓ Down 63 lbs as of February 2026
  • ✓ No visible fat changes observed yet, but weight loss progress resumed on the scale.
  • ✓ Total testosterone increased from 458 to 1100, and free testosterone rose from 63 to 190 while maintaining a calorie deficit.
  • ✓ Maintained 1.5-2lbs/wk weight loss, Dexa scan confirmed a 50% reduction in visceral fat
  • ✓ maintained strength for the most part, slept very well after starting Tesamorelin
  • ✓ Dropped approximately 20 lbs since starting peptide routine in July
  • ✓ Stomach fat 'melting away'
  • ✓ improved sleep, falling asleep easier, waking up less frequently, and feeling more rested

Self-reported community experiences, not verified results.

Sample reported side effects

  • ⚠ No major side effects mentioned, but noted a gelling issue with Tesamorelin when a syringe was dropped.
  • ⚠ Water retention, increased emotional sensitivity, and elevated estradiol (E2) levels rising from 18 to 41.
  • ⚠ not stated
  • ⚠ first two weeks on Retatrutide were rough, decreased endurance
  • ⚠ Tesamorelin caused temporary insomnia/poor sleep only on the first pin of a new vial
  • ⚠ Hate the daily injections, keeps awake at night
  • ⚠ Taste changes, food aversion
  • ⚠ High ALT liver enzymes on Retatrutide. Thymosin Alpha 1 caused severe herx reactions (due to Chronic Lyme) at higher doses, which resolved at the lower 0.8mg dose. Tesamorelin disrupted sleep at 2.0mg, but was tolerated at 1.5mg.