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Epitalon

Also known as: Epithalon, Epithalamin

Longevity Research Compound

Synthetic tetrapeptide (pineal bioregulator)

Mechanism of Action

Tetrapeptide (Ala-Glu-Asp-Gly) studied for telomerase activation and circadian/pineal regulation; longevity claims rest largely on limited animal and small human studies.

874
Community Posts
224
Users Discussing
5
Research Articles
1
Clinical Trials

Reported Outcomes

Clinical grade reflects published research; Community grade reflects user reports (n=874).

Sleep Quality

Effects on sleep quality

Clinical: C
Community: B
47% (252)
Energy Levels

Changes in energy and fatigue levels

Clinical: D
Community: B
19% (61)
Mental/Mood

Effects on mood and cognitive function

Clinical: D
Community: B
16% (56)
Anti-Aging

Anti-aging and regenerative effects

Clinical: C
Community: B
12% (41)
Metabolic Health

Metabolic and cellular health improvements

Clinical: D
Community: B
10% (39)

Who Discusses Epitalon

From community reports with demographic data.

Gender

Male 62%
Female 38%

n=37

Age Distribution (limited data)

52
median age
range: 36-67
30s
40s
50s
60+

n=15

Side Effects

Limited data

Based on 5 user reports (n=5). Frequency indicates how often each was mentioned.

Uncommon (1-5%)

Injection Site Pain
Mild 1 reports 11.1%
Stinging
Mild 1 reports 11.1%
Hair Loss
Mild 1 reports 11.1%
Stinging Upon Injection
Mild 1 reports 11.1%
Skin Tearing And Bruising (Related To Previous Blood Thinner Use)
Mild 1 reports 11.1%
Insane Histamine Reactions
Mild 1 reports 11.1%
Severe Fatigue
Severe 1 reports 11.1%

Risks & Warnings

Important safety considerations based on clinical data and community reports.

i

Injection Site Reactions

20 mentions

Local reactions are common and usually mild. Rotate injection sites.

Dosing

Standard Protocol

Starting Dose
5-10mg daily in cycles (community protocols)
Titration
Cycled (e.g., 10-20 day courses)
Half-life
Short
Administration
Subcutaneous injection

Community Dosing Patterns

Based on 59 mentions

Community-reported patterns, not medical advice.

5mg daily
6
10mg daily
4
500mcg daily
4
1mg daily
3
0.5mg daily
3

Research

5
Total Articles
1
Clinical Trials
1
Reviews

Key Studies

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. Review

J Am Acad Orthop Surg Glob Res Rev (2026)

The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy Preclinical

Stem Cell Rev Rep (2025)

Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity Preclinical

Biogerontology (2025)

AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism Preclinical

Molecules (Basel, Switzerland) (2020)

Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line Preclinical

Int J Mol Sci (2022)

Commonly Stacked With

From community members' documented stacks involving Epitalon.

Retatrutide 18 stacks (25.7%)
Tirzepatide 15 stacks (21.4%)
GHK-Cu 13 stacks (18.6%)
Pinealon 12 stacks (17.1%)
MOTS-c 12 stacks (17.1%)

Switching Patterns

Based on 67 discussions about switching to or from Epitalon.

→ Switching FROM

GHK-Cu 7 mentions
Retatrutide 6 mentions
KPV 4 mentions
Semax 4 mentions

Users who switched to Epitalon

← Switching TO

Retatrutide 8 mentions
Selank 8 mentions
GHK-Cu 7 mentions
KPV 6 mentions

Users who switched from Epitalon