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MOTS-c
Mitochondrial-derived peptide
Mechanism of Action
May improve metabolic function, insulin sensitivity, and exercise capacity. Research is emerging.
MOTS-c: A Mitochondrial-Derived Peptide Under Active Investigation
MOTS-c is one of the few peptides encoded directly by mitochondrial DNA. Preclinical research indicates a single dose improved mouse running distance by 15%, earning it the label "exercise-mimetic peptide." With 84 published articles and 7 clinical trials to date, studies are exploring its potential roles in insulin sensitization, glucose utilization, and metabolic regulation. It remains a research compound with no FDA approval for human use.
Reported Outcomes
Clinical grade reflects published research; Community grade reflects user reports (n=2,197).
Changes in energy and fatigue levels
MOTS-c acts as an exercise mimetic; a single dose in mice improved running time by 12% and distance by 15%. Late-life administration also significantly increased physical capacity and healthspan.
Effects on sleep quality
Metabolic and cellular health improvements
MOTS-c promotes cold adaptation by upregulating brown adipose tissue thermogenic genes and inducing white fat browning. It also reduces lipid trafficking to the liver and prevents metabolic disorders in obesity models.
Effects on mood and cognitive function
In a mouse model of traumatic brain injury (TBI), MOTS-c administration improved memory, learning, and motor function impairments while reducing neuroinflammation.
Anti-aging and regenerative effects
Late-life intermittent MOTS-c treatment has been shown to increase physical capacity and healthspan in mice, and prevent pancreatic islet cell senescence.
Who Discusses MOTS-c
From community reports with demographic data.
Gender
n=83
Age Distribution (limited data)
n=45
Side Effects
Limited dataBased on 12 user reports (n=12). Frequency indicates how often each was mentioned.
Common (>5%)
Uncommon (1-5%)
Risks & Warnings
Important safety considerations based on clinical data and community reports.
Psychiatric Effects
Monitor for mood changes. Report any concerning psychiatric symptoms to healthcare provider.
Injection Site Reactions
Local reactions are common and usually mild. Rotate injection sites.
Dosing
Standard Protocol
- Starting Dose
- 5-10mg weekly
- Titration
- No established protocol
- Half-life
- Unknown in humans
- Administration
- Subcutaneous injection
Community Dosing Patterns
Based on 181 mentions
Community-reported patterns, not medical advice.
Pricing
Research-grade reference pricing for 10mg vial. Prices vary by vendor and quantity. Research chemicals require self-mixing and lack medical oversight. Shipping is not included.
We do not list vendors. Prices are aggregated from community reports and should be treated as rough ranges.
US Research Grade
Single small vial from US domestic vendors
US Research (Bulk)
Per-dose equivalent when buying larger US vials
China Research
Per-vial when buying 10-pack from Chinese vendors
Research
Key Studies
Aging (Albany NY) (2022)
Diabetes Metab Syndr Obes (2023)
Chron Respir Dis (2023)
Front Physiol (2023)
Front Endocrinol (Lausanne) (2023)
Commonly Stacked With
From community members' documented stacks involving MOTS-c.
Switching Patterns
Based on 157 discussions about switching to or from MOTS-c.
→ Switching FROM
Users who switched to MOTS-c
← Switching TO
Users who switched from MOTS-c