MOTS-c + Retatrutide

Mots C + Retatrutide

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34

authors mention this stack

20

ran the components concurrently

MOTS-c + Retatrutide (MOTS-c + Retatrutide) appears in 34 author journeys (20 as actual concurrent use). Common goals: Retatrutide for weight loss and addressing chronic GI issues (slowing digestion); MOTS-c for energy and supporting 2-hour daily cardio sessions; Weight loss and general peptide routine; Energy support, workouts. Typical doses reported: MOTS-c 5mg, Retatrutide 2mg. Reported side effects include: MOTS-c caused mild temporary itchiness (10-40 minutes) and slightly red injection site reactions (ISR)

Typical doses reported

Mots C 5mg
Retatrutide 2mg

Community-reported doses are not medical guidance.

How people are running it

16

Currently running

10

Planning to run

4

Ran in the past

4

Recommended / discussed

What people use it for

Retatrutide for weight loss and addressing chronic GI issues (slowing digestion); MOTS-c for energy and supporting 2-hour daily cardio sessionsWeight loss and general peptide routineEnergy support, workoutsA1C reduction, weight loss, and mitochondrial repairweight loss and maintaining muscle massweight loss, appetite suppression, and lifestyle change

Sample reported outcomes

  • ✓ Resolution of chronic lifelong diarrhea issues, high energy levels, and successful continuation of intensive daily cardio
  • ✓ Experienced significant injection site pain and adrenaline surges.
  • ✓ Energy levels going back up
  • ✓ A1C dropped from 6.5 to 5.6, likely due to a synergistic effect of both peptides
  • ✓ Author lost 10 pounds (8 lbs in the first week) within the first two weeks; wife lost 8 pounds. By week four, the weight loss progress remained solid (wife lost about 13 pounds).
  • ✓ Down to 200lbs, but still experiences body stiffness/pain when sitting still and getting up
  • ✓ Retatrutide resulted in a total weight loss of ~30 lbs (down to 180 lbs). MOTS-c provided a 'noticeable clean energy run' and made the author feel 'sent to the moon' / 'like superman'.
  • ✓ Woke up less stiff, experienced reduced water retention in legs, and saw improved immune markers (T-regs).

Self-reported community experiences, not verified results.

Sample reported side effects

  • ⚠ MOTS-c caused mild temporary itchiness (10-40 minutes) and slightly red injection site reactions (ISR)
  • ⚠ Injection site reaction (droplets of blood, red circle, lump) and anxiety/adrenaline surges.
  • ⚠ Hot flashes in the morning lasting an hour or more, feeling disoriented, initial fatigue
  • ⚠ Aches and itching at the injection site (attributed to MOTS-c)
  • ⚠ Author experienced returning appetite/cravings at the end of each week. Wife experienced mild nausea and increased bowel movements.
  • ⚠ Retatrutide caused sleep disruption (early waking) at 4mg, which was managed by reducing to a 3mg split dose. MOTS-c caused minor injection site issues (bruising, lumps, and minor burning).
  • ⚠ An injection of 200mcg of Vasoactive Intestinal Peptide caused a temporary heart rate spike to 99 bpm and facial flushing.
  • ⚠ No negative side effects reported