MOTS-c + Tirzepatide
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27
authors mention this stack
19
ran the components concurrently
MOTS-c + Tirzepatide (MOTS-c + Tirzepatide) appears in 27 author journeys (19 as actual concurrent use). Common goals: Tirzepatide for weight loss and managing early menopause; MOTS-C to treat chronic fatigue.; Weight loss, managing appetite, addressing lack of response to GLP-1 medications; General discussion on how to stack MOTS-C while on Tirzepatide. Typical doses reported: MOTS-c 5mg, Tirzepatide 5mg. Reported side effects include: MOTS-C caused localized injection site redness, swelling, and burning/stinging that lasted for about 4 hours. Tirzepatide caused sulfur burps and gas when she briefly increased the dose to 5mg.
Typical doses reported
Community-reported doses are not medical guidance.
How people are running it
12
Currently running
7
Ran in the past
6
Planning to run
2
Recommended / discussed
What people use it for
Sample reported outcomes
- ✓ Tirzepatide successfully suppressed food noise and reduced hot flashes. MOTS-C initially provided energy (speed-cleaning) but subsequently caused severe mid-day energy crashes/extreme fatigue.
- ✓ No cessation of food noise or appetite, ravenous, and gaining weight
- ✓ Excellent synergy. Provided clean, non-jittery energy, improved gym/cardio output, and successfully mitigated Tirzepatide-induced fatigue.
- ✓ Beer did not taste the same, stopped drinking
- ✓ Maintained energy levels with no decrease in energy after stopping SS-31
- ✓ MOTS-c gives massive energy after 3 weeks
- ✓ Significant improvement in energy levels, alertness throughout the day, and improved stamina during exercise/hiking.
- ✓ Lost 15 pounds in the first 4 weeks, currently experiencing a weight stall
Self-reported community experiences, not verified results.
Sample reported side effects
- ⚠ MOTS-C caused localized injection site redness, swelling, and burning/stinging that lasted for about 4 hours. Tirzepatide caused sulfur burps and gas when she briefly increased the dose to 5mg.
- ⚠ Sulfur burps, skin feeling sunburned/itchy/painful to touch on arms and legs, feeling like wanting to crawl out of skin, body chills upon scratching
- ⚠ Injection site reaction (ISR) burn/sting
- ⚠ Injection site lumps from MOTS-c that took a week to resolve.
- ⚠ Severe headache after drinking a higher ABV beer
- ⚠ Fatigue from Tirzepatide
- ⚠ Mild injection site reactions from MOTS-C (minor redness and very mild stinging/burning).
- ⚠ Appetite suppression, mild nausea only when forcing self to eat