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NAD+

Also known as: NAD+, Nicotinamide adenine dinucleotide, NAD plus

Longevity Research Compound

Coenzyme / metabolic cofactor

Mechanism of Action

Essential coenzyme in cellular metabolism. Supplementation aims to restore declining NAD+ levels associated with aging.

Note: Precursors (NMN, NR) available as supplements

NAD+ (nicotinamide adenine dinucleotide) generates intense interest as a longevity compound, yet robust evidence remains thin — only 280 unique individuals contribute observational data, and just 1 clinical trial has been identified. Sentiment skews cautiously optimistic: 53 positive versus 11 negative self-reported assessments, though the majority (114) remain neutral — suggesting most individuals are still evaluating outcomes rather than reporting clear benefits.

287
Community Posts
64
Users Discussing
38
Research Articles
5
Clinical Trials

Reported Outcomes

Clinical grade reflects published research; Community grade reflects user reports (n=287).

Sleep Quality

Effects on sleep quality

Clinical: D
Community: B
14% (10)
Anti-Aging

Anti-aging and regenerative effects

Clinical: A
Community: C
9% (8)
Metabolic Health

Metabolic and cellular health improvements

Clinical: C
Community: B
9% (7)

In a model of obesity-induced chronic kidney injury, renal NAD+ levels were found to be depleted; treatment with a GLP-1 receptor agonist restored renal metabolism homeostasis, including NAD+ levels.

Energy Levels

Changes in energy and fatigue levels

Clinical: A
Community: B
8% (6)

Side Effects

Limited data

Based on 2 user reports (n=2). Frequency indicates how often each was mentioned.

Uncommon (1-5%)

Nicotinamide Adenine Dinucleotide Crystalizing
Mild 1 reports 50.0%
Degradation (In Vial)
Mild 1 reports 50.0%
Stinging Twinges At Injection Site
Mild 1 reports 50.0%
Odor (Product Smell)
Mild 1 reports 50.0%

Dosing

Standard Protocol

Starting Dose
100-500mg IV or 250-1000mg oral precursors
Titration
Varies by form (IV, sublingual, oral precursors)
Half-life
Variable by form
Administration
IV infusion, subcutaneous, or oral precursors (NMN, NR)

Community Dosing Patterns

Based on 155 mentions

Community-reported patterns, not medical advice.

50mg daily
8
50mg
7
50mg 2x/week
6
daily
6
100mg 2x/week
5

Pricing

Research-grade reference pricing for 500mg vial. Prices vary by vendor and quantity. Research chemicals require self-mixing and lack medical oversight. Shipping is not included.

We do not list vendors. Prices are aggregated from community reports and should be treated as rough ranges.

US Research Grade

$85

Single small vial from US domestic vendors

US Research (Bulk)

$73.33

Per-dose equivalent when buying larger US vials

China Research

$9.25

Per-vial when buying 10-pack from Chinese vendors

Research

38
Total Articles
5
Clinical Trials
10
Reviews

Key Studies

NAD(+) metabolism-based immunoregulation and therapeutic potential. Review

Cell Biosci (2023)

Defining NAD(P)(H) Catabolism. Review

Nutrients (2023)

NAD metabolism: Role in senescence regulation and aging. Review

Aging Cell (2024)

Homeostatic regulation of NAD(H) and NADP(H) in cells. Review

Genes Dis (2024)

NAD metabolism and heart failure: Mechanisms and therapeutic potentials. Review

J Mol Cell Cardiol (2024)

Commonly Stacked With

From community members' documented stacks involving NAD+.

MOTS-c 100 stacks (41.3%)
Retatrutide 77 stacks (31.8%)
SS-31 72 stacks (29.8%)
Tirzepatide 71 stacks (29.3%)
GHK-Cu 36 stacks (14.9%)

Switching Patterns

Based on 7 discussions about switching to or from NAD+.